{"id":25547128,"date":"2025-06-04T09:33:46","date_gmt":"2025-06-04T09:33:46","guid":{"rendered":"https:\/\/migration.ajiagrosolutions.com\/?p=25547128"},"modified":"2025-06-06T12:36:31","modified_gmt":"2025-06-06T12:36:31","slug":"how-european-regulations-are-driving-complexity-in-crop-protection-formulations","status":"publish","type":"post","link":"https:\/\/www.ajiagrosolutions.com\/nl\/how-european-regulations-are-driving-complexity-in-crop-protection-formulations\/","title":{"rendered":"How European regulations are driving complexity in Crop Protection Formulations"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_row _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221; theme_builder_area=&#8221;post_content&#8221;][et_pb_text _builder_version=&#8221;4.24.0&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; theme_builder_area=&#8221;post_content&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><!-- divi:paragraph -->With mounting regulatory pressure, the crop protection industry is shifting away from new active ingredients and embracing smarter co-formulant-based formulations.<\/p>\n<p><!-- \/divi:paragraph --><!-- divi:heading --><\/p>\n<h2><strong>Navigating the Regulatory Challenges in Europe for Crop Protection: The Case for Advanced Co-Formulants<\/strong><\/h2>\n<p><!-- \/divi:heading --><\/p>\n<h4><strong>Introduction<\/strong><\/h4>\n<p><!-- divi:paragraph -->The European regulatory landscape for crop protection is becoming increasingly restrictive, making it difficult for new active ingredients (AIs) to be developed, approved, and launched. With rising costs, stringent environmental assessments, and a high risk of bans, the industry must find innovative solutions to maintain agricultural productivity. One of the most promising approaches is the optimization of formulations through advanced co-formulants, which enhance the efficacy and complementarity of the remaining approved AIs while improving sustainability. <strong><\/strong><\/p>\n<p><!-- \/divi:paragraph --><!-- divi:image {\"id\":25545980,\"width\":\"600px\",\"height\":\"auto\",\"sizeSlug\":\"large\",\"linkDestination\":\"none\",\"align\":\"center\"} --><!-- \/divi:image --><!-- divi:heading --><\/p>\n<h2><strong>The Challenges of Developing New Active Ingredients<\/strong><\/h2>\n<h4><strong>High Development Costs and Regulatory Challenges<\/strong><\/h4>\n<p><!-- \/divi:heading --><!-- divi:paragraph -->Developing a new crop protection AI is a costly and time-intensive process. On average, it takes 10\u201312 years and an investment of over \u20ac300 million to bring an AI from discovery to market. A significant portion of this cost stems from the extensive safety and environmental assessments required by the European Food Safety Authority (EFSA) and national regulatory bodies.<\/p>\n<h4><img decoding=\"async\" src=\"https:\/\/www.ajiagrosolutions.com\/wp-content\/uploads\/2025\/06\/DEF_Time-and-Cost-To-Market-CP-2024.jpg\" width=\"2160\" height=\"2160\" alt=\"\" class=\"wp-image-25547173 alignnone size-full\" \/><\/h4>\n<p><em>Discovery &amp; Development Costs of a New Active Ingredient (Mean Average)<br \/>Source: <\/em><span><a href=\"https:\/\/croplife.org\/wp-content\/uploads\/2024\/02\/Time-and-Cost-To-Market-CP-2024.pdf\"><em>https:\/\/croplife.org\/wp-content\/uploads\/2024\/02\/Time-and-Cost-To-Market-CP-2024.pdf<\/em><\/a><\/span><\/p>\n<h4><strong>Increasing Risk of Market Bans<\/strong><\/h4>\n<p><!-- \/divi:paragraph --><!-- divi:image {\"id\":25545977,\"width\":\"591px\",\"height\":\"auto\",\"sizeSlug\":\"large\",\"linkDestination\":\"none\",\"align\":\"center\"} --><!-- \/divi:image --><!-- divi:heading -->Once an AI is approved, there is no guarantee it will remain on the market. Under Regulation (EC) No 1107\/2009, active substances undergo periodic review, and many have been withdrawn due to stricter hazard-based cut-off criteria. This regulatory uncertainty significantly increases the financial risk for companies investing in new AIs.<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.ajiagrosolutions.com\/wp-content\/uploads\/2025\/06\/Afbeelding2.png\" width=\"580\" height=\"320\" alt=\"\" class=\"wp-image-25547119 alignnone size-full\" srcset=\"https:\/\/www.ajiagrosolutions.com\/wp-content\/uploads\/2025\/06\/Afbeelding2.png 580w, https:\/\/www.ajiagrosolutions.com\/wp-content\/uploads\/2025\/06\/Afbeelding2-480x265.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 580px, 100vw\" \/><\/p>\n<p><em>Number of Approved Active Ingredients in the EU Over Time<br \/>Source: <\/em><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-24057-7\/figures\/1\">https:\/\/link.springer.com\/article\/10.1007\/s11356-022-24057-7\/figures\/<\/a><\/p>\n<p><!-- \/divi:paragraph --><!-- divi:list --><!-- \/divi:paragraph --><!-- divi:list --><\/p>\n<h4><strong>Additional Regulatory Pressures<\/strong><\/h4>\n<p><!-- \/divi:list-item --><!-- \/divi:list --><!-- divi:heading -->Policymakers are launching projects like the Sustainable Use Directive (SUD) and the Farm to Fork strategy to reduce the use of chemical pesticides by 50% by 2030. Maximum residue levels (MRLs) are also becoming stricter, limiting the global competitiveness of EU agricultural exports.<\/p>\n<h2><strong>Majors&#8217; Response: A Shift in Formulation Strategy<\/strong><\/h2>\n<p>In the early 2000s, a shift began toward high-concentration and multi-AI formulations. Tensiofix supported this transition by helping customers master the technologies to blend AIs effectively and improve stability at higher concentrations.<\/p>\n<p>Later, the rise of volatile organic compound (VOC) restrictions prompted a move toward solid active ingredient formulations like SCs and WDGs. Most recently, oil dispersion (OD) technologies have gained ground due to their built-in adjuvant effect, along with a growing preference for tank-mix and bio-based adjuvants.<\/p>\n<p>Tensiofix, in partnership with Ajinomoto Co. (Japan), is actively developing biobased solutions in this space. The emergence of safer solvents is further driving a return to liquid formats such as EC and EW, backed by tools like COSMO-RS to accelerate development.<\/p>\n<p>The industry has nearly halted the development of new chemical AIs in favor of biocontrol agents (BCAs) and basic substances (Basic AS). We believe that the combination of small amounts of chemical AIs with BCAs through optimized formulations is the future of sustainable pest management.<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.ajiagrosolutions.com\/wp-content\/uploads\/2025\/06\/Afbeelding3.png\" width=\"968\" height=\"583\" alt=\"\" class=\"wp-image-25547123 alignnone size-full\" \/><\/p>\n<p><em>Evolution of Active Substances in Europe: Chemicals vs. Biocontrol Agents<br \/>Source: <\/em><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s11356-022-24057-7\/figures\/1\"><em>https:\/\/link.springer.com\/article\/10.1007\/s11356-022-24057-7\/figures\/4<\/em><\/a><\/p>\n<p>Finally, biostimulants are gaining traction as one of the fastest-growing segments in agriculture. Healthy crops are more resilient, reducing the need for chemical intervention. At Ajinomoto AgroSolutions, we are uniquely positioned to support this shift through our dual expertise in biostimulants and co-formulants.<\/p>\n<h2><strong>Conclusion: The Need for Regulatory Adaptation<\/strong><\/h2>\n<p>While the European regulatory framework aims to enhance sustainability, it also presents significant challenges to innovation. To navigate this environment, the industry must prioritize formulation science and invest in co-formulant technologies that maximize the value of remaining AIs.<\/p>\n<p>Regulatory bodies should also incentivize safer, more effective formulations as part of a balanced crop protection policy. At Ajinomoto AgroSolutions, we are committed to leading this transition \u2014 delivering high-performing, sustainable solutions through innovation and collaboration.<\/p>\n<h2><strong>Let\u2019s Turn Regulatory Pressure Into Your Competitive Advantage<\/strong><\/h2>\n<p>You\u2019re not alone in navigating the complexities of the European regulatory framework. But not everyone has the right partner to stay ahead of it.<\/p>\n<p>At <strong>Ajinomoto AgroSolutions<\/strong>, we combine proven formulation science, a robust regulatory track record, and a dual portfolio of co-formulants and biostimulants \u2014 ready to transform your pipeline.<\/p>\n<ul>\n<li>Want to reformulate a product under pressure?<\/li>\n<li>Looking to combine chemical AIs with biocontrols?<\/li>\n<li>Need to scale a formulation that regulators will approve \u2014 and farmers will trust?<\/li>\n<\/ul>\n<p><strong>Let&#8217;s build yoir next-generation formulation together.<br \/>Reach out today and get direct access to our experts. No bots. No waiting. Just real solutions. <\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><!-- \/divi:paragraph --><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n<div style=\"margin-top: 0px; margin-bottom: 0px;\" class=\"sharethis-inline-share-buttons\" ><\/div>","protected":false},"excerpt":{"rendered":"<p>With mounting regulatory pressure, the crop protection industry is shifting away from new active ingredients and embracing smarter co-formulant-based formulations. Navigating the Regulatory Challenges in Europe for Crop Protection: The Case for Advanced Co-Formulants Introduction The European regulatory landscape for crop protection is becoming increasingly restrictive, making it difficult for new active ingredients (AIs) to [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":25547138,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[104,52,112],"tags":[111,113],"dipi_cpt_category":[],"class_list":["post-25547128","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-co-formulanten","category-coformulants","category-coformulants-fr-2","tag-crop-protection-formulations-nl","tag-la-formulation-des-produits-phytosanitaires"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.3 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How European regulations are driving complexity in Crop Protection Formulations - Ajinomoto - Agrosolutions<\/title>\n<meta name=\"description\" content=\"Learn how biostimulants combat plant stress, improve resilience, and enhance sustainable food production. 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